User blog comment:Doctor Ibrahim/Ask the Doc and his Family!/@comment-28530195-20160811001750/@comment-28358106-20160811020450

Me: "It would be difficult, but not impossible.  It would require runes that are able to manipulate the states of the bodily material without atmospheric interference.  Basically transmutation of the body based off of predetermined programmed runes.  She would have to have a solid nucleus, small, but still solid, as an anchor for the runes, and she wouldn't be able to grow her mass again, unless she was able to transmute other materials into her own, and transmutation via constructed intelligences requires either an enormous amount of energy or a very large runic algorithm to work out the variables.  She would likely lack most of the improvisational abilities that an organic Shoggoth has."