Well, since it is kind of topic with the MGE world as well I'll try to explain why that way of reasoning isn't true. We can discuss things in a civilized manner like adults, no?
Human intellect is a trait of natural evolution, which plays a massive role in transhumanism, we can all agree on that. Now, Our technology is the pinnacle of Human achievement which evolved alongside us by us Humans for us Humans. No one is forcing people who want or don't want to use it. It is out there, available for anyone who want to use it. Technology isn't good or evil, it's application is purely dependent of the morality of its user.
Now, with that cleared, any piece of tech that can in any way alter/advance an individual is nothing but our achievement that is available for our use, if we want. As long as such tech is available for anyone to use, and is use is strictly voluntary, a matter of ones choice what they and they alone decide for their future, there is nothing wrong with it.
Now, if a group goes around forcing it on everyone regardless of their choice, then that's a problem and it is wrong. DE does not give a damn and it is outright forced on anyone in contact with it.
That's for technological aspect of it. If we use a sci-fi model of it, more similar to the one in MGE, with Humanity reaching to the point when we can achieve such state with our minds, then again, everyone has the same potential of success, one we reached as a collective, a species. It does not go against natural evolution, rather it is the product of it, since it was natural evolution that made us reach that point. Once advanced to such a state we no longer would need the old slow process of evolution which is based on the principle of trial and error, but that process wouldn't go away just because we made a far more effective way for it. This is a much more 'transparent' form of it as it does not leave much room to force it on others. The best example would be Saitama, despite being a sort of parody. His own willpower and determination and his hard work is what helped him broke the limiters of human potential, while DL forces DE which is worse that Monster cells from OPM as those again can be ingested strictly by ones own free will.
If the process is a combination of technology and human mind, the principle is the same, as long as everyone has access to it and there's no people running around forcibly ascending people, then there's no issue. Again, with the DE this is non negotiable, it is forced on everyone whether they like it or not.
The thing that the DL knows that fact about DE and has in fact made it to be that way willingly, she's sticking her nose in other people's lives, forcing on them something she has no right to do. DE as it is presented in setting is the 99% of what's wrong in the MGE world as it imposes someone else's will and Ideals even life stile and life choices onto everyone regarding of their consent, and last time I checked that's called terrorism.
In MGE, since there are multiple sentient species, the term Transhumanism would be adapted to encompass all sentient beings that are collectively pouring their knowledge in the technology. That's simply because thecnology is like a living organism constantly evolving as individuals with vision adapt it, Mamono are using Human inventions and viceversa, and smart minds are constantly adding, improving, expanding onto its functionality because it is a useful thing for everyone. As it proliferates among the population, again someone with vision will further adapt it ...rinse repeat.
I hope it is understandable enough for people to get why I think that way and why I do not agree with Lilith's way. I do respect her intention, though, as it stems from a rather noble idea, but the way she went with it is from my own point of view not on the most morally right ones. Of course, this is what I think about it, everyone has the right to form their own opinion on the matter.